Gout
Gout is caused by increase in Uric Acid concentration in blood leading to deposits of its crystals in and around joints
Gout can be genetic but can be caused by kidney disease and obesity
Uric acid is a product of Purine (protein) metabolism and diet rich in protein can precipitate gout attack
Alcohol ingestion can alter Purine metabolism to produce more uric acid
Classic gout occurs at the base of big toe (1st MTP joint), it causes swelling, redness, warmth and intense throbbing pain
Almost any joint can be affected by gout
Treatment: NSAIDs, Colchicine, Steroids
For frequent gout attacks —> prevention is recommended with Allopurinol and dietary modification